English
norskBlar i forfatter "Ludvigsen, Stian"
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Cardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)Aim of study was to examine experimentally the adult female hypertensive heart in order to determine the role of ovary function in the response of the heart to salt-dependent hypertension. Dahl salt-sensitive rats, age 12 weeks, with/without ovariectomy were fed a standard (0.3% NaCl) or high-salt diet (8%) for 16 weeks. Mean arterial blood pressure monitored noninvasively in conscious state ... -
Evoked potentials in the Atlantic cod following putatively innocuous and putatively noxious electrical stimulation: a minimally invasive approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Aspects of peripheral and central nociception have previously been studied through recording of somatosensory evoked potentials (SEPs) to putative noxious stimuli in specific brain regions in a few freshwater fish species. In the present study, we describe a novel, minimally invasive method for recording SEPs from the central nervous system of the Atlantic cod (Gadus morhua). Cutaneous ... -
Gender differences in hearts subjected to decreased NO-production and elevated blood pressure
(Master thesis; Mastergradsoppgave, 2016-10-31)Hypertension is one of the most important risk factors for heart failure in the general population. Hypertensive heart failure is associated with heart failure with preserved ejection fraction (HFpEF). Women have an increase proportion of HFpEF compared to men. Endothelial dysfunction thereby reduced NO production is proposed to play an important role in the pathophysiology of HFpEF. A suggested ... -
Heart Angiotensin- Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-19)Angiotensin-converting enzyme 2 (ACE 2) in the heart including its sex dependency in the hypertensive heart, has not been much studied compared to ACE. In the present study, we used the Dahl salt-sensitive rat exposed to fructose and salt to model a hypertensive phenotype in males, females, and ovariectomized females. Blood pressure was measured by the tale-cuff technique in the conscious state. ... -
Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-19)Angiotensin-converting enzyme 2 (ACE 2) in the heart including its sex dependency in the hypertensive heart, has not been much studied compared to ACE. In the present study, we used the Dahl salt-sensitive rat exposed to fructose and salt to model a hypertensive phenotype in males, females, and ovariectomized females. Blood pressure was measured by the tale-cuff technique in the conscious state. ... -
Neuronal hypoxia tolerance in diving endotherms
(Doctoral thesis; Doktorgradsavhandling, 2010-08-20)The thesis “Neuronal hypoxia tolerance in diving endotherms” sheds light on mechanisms giving diving animals, such as the hooded seal, impressive dive capabilities of 1 hr duration down to 1000 m depth. In spite of enhanced capacity to store oxygen in their body and an ability to reduce their oxygen-consumption, these animals can resurface with blood oxygen values so low that a human being in the ...
